Project title: Laser Surface Texturing and Coating of Ti-6Al-4V for Improving Biocompatibility
Other PhD projects in Mechanical Engineering
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| PhD student: | Nazanin Mirhosseini |
| Qualification: | PhD, MSc, BEng |
| Country: | Iran |
| Sponsor: | School of Mechanical, Aerospace and civil Engineering |
| Expert group: | |
| Research group: | Manufacturing and Management, Faculty of Life Sciences |
| Collaboration: | Rolls-Royce, Faculty of life sciences, Johnson and Johnson, School of Biomedicine |
| Awards: |
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| Personal page: | |
| Email: | nazanin.mirhosseini@manchester.ac.uk |
| Supervisor: | Prof Lin Li, Prof David Garrod |
Professional Biography:I completed my first degree in Mechanical Engineering in Iran University of Science and Technology (IUST, Iran 1998). I then worked for a year as a junior design engineer, designing energy test rooms (Ashena Tech. Co. 1998-1999). Following that I worked in a Manufacturing Company (Iran Radiator Co. 2000-2002) as a senior design engineer for a year and then was appointed as the head of design department focusing on designing automotive radiators and industrial heat exchangers. I moved to UK in 2002 where I completed a MSc. course in Advanced Manufacturing Technology and Systems Management (UMIST, 2002-2003, Distinction dissertation on Thin film metal oxide coating on glass). I continued the research on laser manufacturing as an Academic Visitor (UMIST, 2003-2004) and then completed a PhD in Biomechanics (The University of Manchester, 2004-2009) working on Laser surface texturing and coating of Ti-6Al-4Vfor improving biocompatibility. I started working as a Postdoctoral Research Associate in the School of Biomedicine, University of Manchester in January 2010 where I am working on Improving the Biocompatibility of Heart Stents in collaboration with Johnson and Johnson.
Research interests: Laser micro/nano-processing, Laser bioactive deposition, Cell attachment and cell morphology on different substratum, Cell rejection on different substratum, Implant-protein interactions.
Project abstract
The project aimed to understand how lasers modify surface characteristics such as topography and chemistry, to improve the biocompatibility and osteoblast (bone) cell attachment of a titanium alloy Ti-6Al-4V. Various laser textured surfaces and a laser/sol-gel coating were analysed to find the highest level of cell attachment. Bio imaging was performed to observe the cell morphology on different substrates and to localise focal contacts.
| Fig 1. SEM micrographs of laser structured Ti-6Al-4V | Fig 2. Florescence microscopy of stress fibres (in green) and focal contacts (in red) of an osteoblast cell on blank (untreated) Ti-6Al-4V after 22 hours in culture | _Garrod_2004_Mirhosseini_Figure1_1.JPG) |
_Garrod_2004_Mirhosseini_Figure2_2.JPG) |
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Publications
Journal Papers
- N. Mirhosseini, P.L. Crouse , L. Li , D. Garrod , Combined laser/sol gel synthesis of calcium silicate coating on Ti–6Al–4V substrates for improved cell integration, Applied Surface Science 253, 7998–8002, 2007.
- N Mirhosseini, P.L. Crouse, M.J.J. Schmidt, L. Li, D. Garrod, Laser surface micro-texturing of Ti-6Al-4V substrates for improved cell integration. Applied Surface Science, 253(19), 7738-7743, 2007.
- Growth of patterned thin metal oxide films on glass substrates from metallic bulk sources using a Q-switched YAG laser, Applied Surface Science 248, 204-208, 2005.
Conference Papers
- N.Mir-hosseini, D.Whitehead and Lin Li, Excimer Laser Surface Micro-Texturing of Ti-6Al-4V for Improved Cell Integration, The 5th International Conference on Laser Material Processing (LAMP) 2009, Japan (accepted for publication).
- v. Laser surface texturing of Ti-6Al-4V and controlled oxide formation for improving biocompatibility, ICALEO Conference 2005, Florida, USA.
Other Contributions
- Patent: Nazanin Mirhosseini, Lin Li, David Garrod, A method for improving cell adhesion to medical implants (patent application in progress through UMIP).